Viagra Side Effects Long-Term UseLong-Term Effects of Using Viagra | LIVESTRONG.COM
Jan 24, 2010 ... The use of Viagra can cause side effects affecting multiple organ systems in the body. Additionally, long-term use of this drug can potentially ...
Viagra Side Effects Long-Term Use
Long-term viagra use can increase the potential to develop psychological dependency. Each treatment year, less than 1 of the men who started the year discontinued sildenafil because of treatment-related adverse events, for a total of only 11 (1. Of the 979 participants who entered the sildenafil long-term extension study, 584 (60) completed all 4 years.
Pooled data also support the efficacy of sildenafil results from 11 double-blind, flexible-dose, placebo-controlled trials that included a total of 2,667 men ages 23 to 89 years with ed of broad-spectrum etiology show significantly improved erectile function for sildenafil compared with placebo as measured by the international index of erectile function, a global efficacy question, and a patient-recorded event log of sexual activity ( the population of the current 4-year open-label study of sildenafil differed from those of the pooled double-blind studies in that it was self-selected. Long-term use of viagra can also increase the risks for double vision and temporary vision loss. This was a 4-year, open-label, flexible-dose (25, 50, and 100 mg) study of sildenafil.
Also, men who could afford to purchase sildenafil may have lost incentive to participate in the long-term study when sildenafil became commercially available. After 629 days of therapy, at which time his dosage was once again 100 mg, he permanently discontinued sildenafil because of the flushing. Viagra prompted the food and drug administration (fda) to add this serious side effect on the warning labels.
Jewell trained in clinical research medicine in cancer and aidshiv at nih and ucla. Men who previously completed and were compliant with sildenafil or placebo treatment in 1 of 4 double-blind, placebo-controlled trials, and subsequently completed and were compliant with sildenafil treatment in initial open-label extension, were eligible for inclusion in this long-term extension study. The retention rate was 84 (818979) the first year, 75 (731979) the second year, and 66 (648979) the third year the entire 4-year extension study was completed by 584 of the initial 979 men (60) ( ).
Suite 512, huntsville, al 35801, usa tel 1 256 533 6603 fax 1 256 564 7150 email because sildenafil citrate is a treatment, not a cure, for erectile dysfunction (ed), many men may choose to use it for an extended period. She is a health blogger and producer, and currently produces several webisodetv series on how-tos on health and living green. Therefore, only serious adverse events and adverse events leading to changes in dosing or to temporary or permanent discontinuation were recorded and evaluated by the investigators for relatedness to sildenafil treatment.
Adverse events that were serious or led to dosing changes or discontinuation (temporary or permanent) were recorded. Discontinuations were caused by dyspepsia (n 4), rhinitis (n 2), abnormal vision plus headache (n 1), dyspepsia plus rhinitis (n 1), and flushing, dizziness, and myalgia (n 1 each). A total of 1,545 men were originally enrolled in the double-blind trials, with 1,358 of these men continuing in the initial open-label extension studies. Additional side effects can include issues relating to urinary tract functions, for example, incontinence, increase risk for urinary tract infections, and cystitis. Dailymed, an online site providing information on fda approved drugs by the national library of medicine, cited retinal hemorrhaging and vascular diseases as potentially serious side effects of viagra.
Long-term safety and effectiveness of sildenafil citrate in men with ...
Adverse events that were serious or led to dosing changes or ... affirmatively to the questions: “Are you satisfied with the effect of treatment on your erections? ... Of the 979 participants who entered the sildenafil long-term extension study, 584 ... Usage of flexible-dose (25, 50, and 100 mg) sildenafil over 2–1561 days by the ...
Viagra Side Effects Long-Term UseNightly Viagra May Restore Normal Erections - WebMD
May 13, 2004 ... Men who take Viagra every night may experience a return to normal ... the long- term effects of taking erection-promoting therapy on a daily ...
Viagra Side Effects Long-Term Use Also, men who could afford to purchase sildenafil may have lost incentive to participate in the long-term study when sildenafil became commercially available, At the time the study started. Adverse events that led to changes in dosing or to temporary or permanent discontinuation other treatment-related aes were abnormal vision (n 4), dizziness (n 3), At the completion of each year, at least 94 of the annually decreasing number of participants reported satisfaction with the effect of sildenafil treatment on their erections. Regardless, Each treatment year, less than 3 of the men who started the year discontinued sildenafil treatment because of insufficient clinical response. May 13, 2004. Long-term use of viagra can also increase the risks for double vision and temporary vision loss.
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Does Viagra have negative long-term effects? - Quora
At each yearly assessment, more than 94 of participants responded affirmatively to the questions are you satisfied with the effect of treatment on your erections? And if yes, has treatment improved your ability to engage in sexual activity? These results argue against the loss of tolerability or the development of tachyphylaxis over a prolonged period of as needed, flexible-dose sildenafil treatment of men with ed. Over the 4 years of the study, only 62 (6. Median duration of participation in the open-label, long-term extension study was 4 years, the median number of doses taken was 420 (range, 11469) ( ), and the preferred dose was 100 mg in more than 88 of the men. For the satisfaction analyses, n is equal to the number of men who answered the satisfaction question. Therefore, only serious adverse events and adverse events leading to changes in dosing or to temporary or permanent discontinuation were recorded and evaluated by the investigators for relatedness to sildenafil treatment.
The efficacy, safety, and tolerability of sildenafil in the treatment of men with ed have been demonstrated in numerous studies of 1-year duration or less. Long-term use can increase the frequencies of dyspepsia and intestinal problems, such as, diarrhea and gastritis. Nih consensus development panel on impotence 1993 overall, 979 men initially agreed to participate in the study, most of whom were white (89) and whose mean age was 58 years ( ). Cardiomyopathy (enlarged heart), arrhythmia (irregular heartbeat), and heart palpitations have been reported. Because serious adverse events are collected for a longer period (30 days after the completion of treatment) than adverse events in general, numbers of events may vary between these 2 databases.
Before approval, sildenafil was evaluated in 18 phase iiiii double-blind, placebo-controlled trials, in which men with ed were randomized to receive treatment with sildenafil (n 2722) or placebo (n 1552) for up to 6 months ( ). Each treatment year, less than 3 of the men who started the year discontinued sildenafil treatment because of insufficient clinical response. The population included patients with ed of organic and psychogenic etiology and typical concomitant medical conditions for this population (ie, hypertension, diabetes, hyperlipidemia, and a history of ischemic heart disease). Livestrong is a registered trademark of the livestrong foundation. Viagra prompted the food and drug administration (fda) to add this serious side effect on the warning labels. Regardless, the results add to the previously published reports by showing continued safety and effectiveness during prolonged treatment. Some reports of anorgasmia or the inability to ejaculate, including abnormal ejaculation, have been documented. Of the few cardiovascular events determined by the investigator to be treatment related (4 cases of mild flushing and 1 each of moderate flushing, mild palpitations, and moderate tachycardia), only 1 led to permanent discontinuation. Two other cardiovascular events led to temporary discontinuation (mild flushing and moderate tachycardia), and the remainder were addressed with a change in dosing. The majority of men were satisfied with sildenafil treatment for their ed and reported improved ability to engage in sexual activity.Viagra is the brand name for sildenafil citrate, a phosphodiesterase-5 inhibitor. It was originally ... medication). Viagra has side effects for multiple organ systems. ... What are the long term effects of Adderall, Dexedrine, or Ritalin use? What are ...